Shortcut to mycothiol analogues

Authors

  • Spencer Knapp Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, 08858-8087
  • Silvia Gonzalez Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, 08858-8087
  • David S. Myers Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, 08858-8087
  • Lisa L. Eckman Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, 08858-8087
  • Carole A. Bewley Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, 08858-8087

Abstract

The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min-1 mg-protein-1, vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.

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Author Biography

Silvia Gonzalez, Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, 08858-8087

Rutgers Undergraduate Research Fellow

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Published

2004-10-31

How to Cite

Knapp, S., Gonzalez, S., Myers, D. S., Eckman, L. L., & Bewley, C. A. (2004). Shortcut to mycothiol analogues. The Rutger Scholar, 6. Retrieved from https://rutgersscholar.libraries.rutgers.edu/index.php/scholar/article/view/77

Issue

Vol. 6 (2004)

Section

Articles